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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: Jun 11, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

TP53 gene mutations in prostate cancer progression.

Thorsten H Ecke1, Horst H Schlechte, Katrin Schiemenz

  • 1HELIOS Hospital, Department of Urology, Bad Saarow, Germany. thorsten.ecke@helios-kliniken.de

Anticancer Research
|July 2, 2010
PubMed
Summary

TP53 mutations in prostate cancer (PCa) predict tumor progression. These mutations are more significant indicators of recurrence than tumor stage or PSA levels.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Last Updated: Jun 11, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

  • Oncology
  • Genetics

Background:

  • Prostate cancer (PCa) remains a significant health concern.
  • Predictive biomarkers for PCa progression are crucial for effective management.

Purpose of the Study:

  • To evaluate the predictive value of TP53 mutations.
  • To assess the role of prostate-specific antigen (PSA) in PCa tumor progression.

Main Methods:

  • Analysis of 90 PCa patient tissue samples from radical prostatectomy.
  • TP53 mutation screening using temperature gradient gel electrophoresis (TGGE).
  • Tumor progression assessment via PSA levels and metastasis detection.

Main Results:

  • TP53 mutations were identified in 35.6% of patients.
  • Patients with TP53 mutations showed a higher rate of tumor progression (40.6%) compared to wild-type (15.5%).
  • TP53 mutations were associated with progression at 25 months, while wild-type progression occurred at 45 months.

Conclusions:

  • TP53 mutations, particularly in exons 7 and 8, are significant predictors of PCa tumor progression.
  • TP53 mutation status offers greater predictive power for tumor recurrence than tumor stage or pre-treatment PSA levels.