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Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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Thyroid function in breast cancer patients.

Nina Ditsch1, Susanne Liebhardt, Franz Von Koch

  • 1Department of Obstetrics and Gynecology - Grosshadern, Ludwig Maximilians University, Munich, Germany. nina.ditsch@med.uni-muenchen.de

Anticancer Research
|July 2, 2010
PubMed
Summary
This summary is machine-generated.

Thyroid hormone levels (fT3, fT4) and thyroid antibodies (TRAK) were significantly higher in breast cancer patients compared to benign breast tumor patients and healthy controls. These findings suggest a link between thyroid function and breast cancer development.

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Area of Science:

  • Endocrinology
  • Oncology
  • Thyroid Research

Background:

  • Emerging evidence suggests a connection between hypothyroidism and breast cancer.
  • Thyroid hormones exhibit estrogen-like effects on breast cancer cell proliferation in vitro.
  • This study investigates thyroid function in women diagnosed with breast cancer, benign breast conditions, and healthy individuals.

Purpose of the Study:

  • To evaluate and compare thyroid function markers in breast cancer patients versus benign breast tumor patients and healthy controls.
  • To explore potential associations between thyroid hormone levels, thyroid antibodies, and breast cancer incidence.

Main Methods:

  • A comparative study involving breast cancer patients (n=65), carcinoma in situ (n=13), benign breast tumor patients (n=27), and healthy controls (n=38).
  • Assessment of thyroid hormones (free triiodothyronine [fT3], free thyroxine [fT4], thyroid-stimulating hormone [TSH]) and thyroid antibodies (thyroid peroxidase [TPO], thyrotropin receptor antibody [TRAK], thyroglobulin [TG]).
  • Statistical analysis using Mann-Whitney U and Fisher's exact tests to determine significance (p<0.005).

Main Results:

  • Breast cancer patients exhibited significantly higher levels of fT3 and fT4 compared to both healthy controls (p<0.001) and benign breast tumor patients (p=0.021 for fT3, p=0.017 for fT4).
  • Thyroid-stimulating hormone (TSH) levels were highest in the control group, though not reaching statistical significance.
  • Breast cancer patients showed significantly elevated TRAK antibody levels compared to women with benign breast tumors (p=0.048).

Conclusions:

  • Significant differences in fT3, fT4, and TRAK levels were identified across the study groups (breast cancer, benign breast tumor, and healthy controls).
  • These findings indicate a potential relationship between specific thyroid function markers and breast cancer.
  • Further research with larger cohorts is warranted to elucidate the precise role of thyroid function in breast cancer.