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Updated: Jun 11, 2026
11:27
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Published on: April 29, 2014
Surgery for renal cell carcinoma metastases
Rodney H Breau1, Michael L Blute
1Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
Current Opinion in Urology
|July 2, 2010
Summary
Metastatic renal cell carcinoma (mRCC) treatment should include surgery for potential cure. Aggressive surgical resection of mRCC offers long-term survival for select patients.
Area of Science:
- Oncology
- Surgical Oncology
Background:
- Molecular targeted therapy has advanced metastatic renal cell carcinoma (mRCC) treatment.
- Cure for mRCC remains uncommon without surgical intervention.
Purpose of the Study:
- To review the current role of metastasectomy in mRCC.
- To identify factors associated with outcomes after metastasectomy for mRCC.
Main Methods:
- Review of recent large observational studies on mRCC.
- Analysis of prognostic factors in patients undergoing metastasectomy.
Main Results:
- Recent studies have clarified prognosis for mRCC patients with or without metastasectomy.
- Key prognostic factors for survival in mRCC patients treated with metastasectomy have been identified.
Conclusions:
- Multimodal therapy, including surgery, should be considered for mRCC.
- Aggressive surgical resection can lead to long-term survival in a subset of mRCC patients.
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