Related Experiment Video
Updated: Jun 11, 2026
07:48
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
A fork in the path: Developing therapeutic inroads with FoxO proteins
Kenneth Maiese1, Jinling Hou, Zhao Zhong Chong
1Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA. kmaiese@med.wayne.edu
Oxidative Medicine and Cellular Longevity
|July 2, 2010
Summary
Mammalian forkhead transcription factors of the O class (FoxOs) regulate key cellular processes. This review explores their complex roles in cellular injury, metabolism, and disease, highlighting therapeutic potential.
Area of Science:
- Molecular Biology
- Cellular Biology
- Genetics
Background:
- Novel therapeutic strategies are needed for complex disorders.
- Mammalian forkhead transcription factors of the O class (FoxOs) are critical regulators of cellular processes.
- FoxOs (FoxO1, FoxO3, FoxO4, FoxO6) influence proliferation, metabolism, inflammation, and longevity.
Purpose of the Study:
- To discuss the multifaceted roles of FoxOs in cellular injury and oxidative stress.
- To explore the involvement of FoxOs in progenitor cell development, fertility, angiogenesis, cardiovascular function, metabolism, diabetes, longevity, immune surveillance, and cancer.
- To highlight the potential of FoxOs as therapeutic targets.
Main Methods:
- Literature review and synthesis of current research on FoxO function.
- Analysis of signaling pathways integrated with FoxOs, such as erythropoietin and Wnt proteins.
- Discussion of the dual role of FoxOs in promoting cell survival or injury.
Main Results:
- FoxOs are central to cellular responses to stress, including oxidative stress.
- FoxOs play significant roles in diverse physiological and pathological processes.
- The function of FoxOs can be context-dependent, acting as a "double-edge sword".
Conclusions:
- FoxOs represent promising therapeutic targets for a wide range of disorders.
- Understanding the complex regulation of FoxOs is crucial for developing effective treatments.
- Further research into FoxO signaling pathways will advance clinical care.
Related Concept Videos
01:16TGF - β Signaling Pathway
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
02:37Restarting Stalled Replication Forks
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...