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A fork in the path: Developing therapeutic inroads with FoxO proteins

Kenneth Maiese1, Jinling Hou, Zhao Zhong Chong

  • 1Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, USA. kmaiese@med.wayne.edu

Oxidative Medicine and Cellular Longevity
|July 2, 2010
PubMed

Insights

Mammalian forkhead transcription factors of the O class (FoxOs) regulate key cellular processes. This review explores their complex roles in cellular injury, metabolism, and disease, highlighting therapeutic potential.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Genetics

Background:

  • Novel therapeutic strategies are needed for complex disorders.
  • Mammalian forkhead transcription factors of the O class (FoxOs) are critical regulators of cellular processes.
  • FoxOs (FoxO1, FoxO3, FoxO4, FoxO6) influence proliferation, metabolism, inflammation, and longevity.

Purpose of the Study:

  • To discuss the multifaceted roles of FoxOs in cellular injury and oxidative stress.
  • To explore the involvement of FoxOs in progenitor cell development, fertility, angiogenesis, cardiovascular function, metabolism, diabetes, longevity, immune surveillance, and cancer.
  • To highlight the potential of FoxOs as therapeutic targets.

Main Methods:

  • Literature review and synthesis of current research on FoxO function.
  • Analysis of signaling pathways integrated with FoxOs, such as erythropoietin and Wnt proteins.
  • Discussion of the dual role of FoxOs in promoting cell survival or injury.

Main Results:

  • FoxOs are central to cellular responses to stress, including oxidative stress.
  • FoxOs play significant roles in diverse physiological and pathological processes.
  • The function of FoxOs can be context-dependent, acting as a "double-edge sword".

Conclusions:

  • FoxOs represent promising therapeutic targets for a wide range of disorders.
  • Understanding the complex regulation of FoxOs is crucial for developing effective treatments.
  • Further research into FoxO signaling pathways will advance clinical care.
Keywords:
agingangiogenesisapoptosiscancerdiabetesimmune systemischemianeurodegenerationoxidative stressstem cells

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