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Updated: Jun 11, 2026
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium-catalyzed hydroxylation of unactivated tertiary C-H bonds
1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Abstract:
The combination of catalytic RuCl(3) and pyridine with KBrO(3) as the stoichiometric oxidant is shown to efficiently promote the hydroxylation of unactivated tertiary C-H bonds. Substrates possessing different polar functional groups--ester, epoxide, sulfone, oxazolidinone, carbamate, and sulfamate--are found to engage in this reaction to give alcohol products in yields generally exceeding 50%. As judged based on efficiency, ease of operation, substrate scope, and selectivity toward tertiary C-H centers, the method appears competitive with other C-H hydroxylation processes.
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