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Published on: December 4, 2016
An enhanced thirteen-week bioassay as an alternative for screening for carcinogenesis factors
1University of Nebraska Medical Center, Omaha, NE 68198-3135, USA. scohen@unmc.edu
Abstract:
Utilizing basic concepts of chemical carcinogenesis and the human relevance framework based on mode of action analysis of animal carcinogens, an alternative is proposed for the two-year bioassay for screening chemicals for potential carcinogenic risk in humans. This model includes short-term screening of chemicals for DNA reactivity, immunosuppressive and, estrogenic activity, and potential increased cell proliferation. Follow-up studies can provide detailed information with regard to dose response and mode of action, with a detailed evaluation of potential relevance to humans. It is no longer appropriate to continue performing two year rodent bioassays.
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