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Updated: Jun 11, 2026

The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
Published on: November 18, 2009
Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal
Zuzana Koledova1, Alwin Krämer, Leona Raskova Kafkova
1Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. zkoledova@gmail.com
Abstract:
Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette.
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