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Updated: Jun 11, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Preventing late-life depression: a clinical update.

Robert C Baldwin¹

¹University of Manchester and Manchester Mental Health Trust, Edale House, Manchester Royal Infirmary, Oxford Rd, Manchester M13 9BX, UK. robert.baldwin@mhsc.nhs.uk

International Psychogeriatrics

|July 3, 2010

Summary

Preventing late-life depression is crucial. Selective and indicated prevention strategies show promise, with antidepressant medication and Problem-Solving Treatment being effective interventions. More research into collaborative care models and economic impact is needed.

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Area of Science:

Geriatric Psychiatry
Preventive Medicine
Mental Health Research

Background:

Late-life depressive disorder presents significant challenges in achieving remission.
Preventing depression in older adults is a critical public health goal.
Recent clinical studies have explored the feasibility of depression prevention in the elderly.

Purpose of the Study:

To review the literature on the primary prevention of late-life depressive disorder.
To identify effective strategies for preventing depression in older adults.

Main Methods:

A focused literature review was conducted on studies published since 2000.
The review prioritized studies on primary prevention of late-life depression or those with prevention as a secondary outcome.

Main Results:

Selective primary prevention is effective for conditions like stroke and macular degeneration, and potentially for depression linked to dementia caregiving.
Indicated prevention shows effectiveness in individuals with subthreshold depression and risk factors like functional limitations.
Universal prevention lacks an evidence base, though population approaches may reduce suicide rates; promising risk factors include diet, exercise, and managing vascular health.

Conclusions:

Antidepressant medication and Problem-Solving Treatment are effective interventions for preventing late-life depression.
Integrating these interventions into care models like collaborative care demonstrates feasibility.
Further economic studies are necessary to evaluate the cost-effectiveness of prevention strategies.