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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Microstructural changes and atrophy in brain white matter tracts with aging.

Stefania Sala1, Federica Agosta, Elisabetta Pagani

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

Neurobiology of Aging
|July 3, 2010
PubMed
Summary

Aging causes changes in brain white matter (WM) microstructure and volume. Diffusion tensor imaging reveals age-related increases in mean diffusivity and decreases in fractional anisotropy across major WM tracts.

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Area of Science:

  • Neuroimaging
  • Aging Research
  • White Matter Integrity

Background:

  • Brain white matter (WM) undergoes structural changes with aging.
  • Understanding these changes is crucial for cognitive health in aging populations.

Purpose of the Study:

  • To investigate age-related microstructural and volumetric abnormalities in major brain white matter tracts.
  • To characterize the relationship between aging and diffusion tensor imaging metrics.

Main Methods:

  • Diffusion tensor (DT) magnetic resonance imaging (MRI) tractography was employed.
  • 84 healthy subjects were analyzed to assess white matter integrity.
  • Linear and quadratic models were used to analyze age-related changes.

Main Results:

  • Age correlated with increased mean diffusivity (MD) and decreased fractional anisotropy (FA) in most WM tracts.
  • Quadratic models better described changes in specific tracts like the corpus callosum.
  • Age-related MD/FA changes were linked to increased radial diffusivity; axial diffusivity varied by tract.

Conclusions:

  • Diffusion tensor imaging reveals significant age-related alterations in white matter microstructure and volume.
  • These findings contribute to understanding the complex pathological substrates of WM changes during aging.