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[Lipoproteins].

C Manso1

  • 1Instituto de Química Fisiológica, Faculdade de Medicina, Lisboa.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

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This review covers plasma lipid transport, lipoproteins, and enzymes. It explores lipid transfer proteins and the origins of atherosclerosis linked to cholesterol metabolism and free radicals.

Area of Science:

  • Biochemistry
  • Physiology
  • Molecular Biology

Context:

  • Plasma lipid transport is crucial for delivering energy and building blocks to various organs.
  • Lipoproteins, enzymes, and lipid transfer proteins are key players in regulating lipid homeostasis.
  • Atherosclerosis is a complex disease with multifactorial origins.

Purpose:

  • To review the intricate mechanisms of plasma lipid transport.
  • To describe the composition and function of plasma lipoproteins and associated enzymes.
  • To discuss the role of lipid transfer proteins and analyze the origins of atherosclerosis.

Summary:

  • The review details plasma lipoprotein composition and the enzymatic machinery involved in lipid metabolism.
  • It examines the function of lipid transfer proteins in modulating lipoprotein structure and function.

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  • The pathogenesis of atherosclerosis is linked to disruptions in cholesterol metabolism, transport, and oxidative stress from free radicals.

    • Impact:

    • Provides a comprehensive overview of lipid transport pathways relevant to metabolic diseases.
    • Highlights the interplay between lipoproteins, enzymes, and proteins in maintaining lipid balance.
    • Offers insights into the molecular basis of atherosclerosis for potential therapeutic targets.