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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Jiaqiang Cai1, D Jonathan Bennett, Zoran Rankovic
1Merck Research Laboratories, MSD, Newhouse, Lanarkshire ML1 5SH, UK. jiaqiang.cai@merck.com
Bioorganic & Medicinal Chemistry Letters
|July 3, 2010
Abstract:
Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors.
