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Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
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Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...

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Related Experiment Video

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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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One-hour postload plasma glucose levels are associated with kidney dysfunction.

Elena Succurro1, Franco Arturi, Marina Lugarà

  • 1Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Catanzaro, Italy.

Clinical Journal of the American Society of Nephrology : CJASN
|July 3, 2010
PubMed
Summary

A 1-hour postload plasma glucose (1hPG) level of 155 mg/dl or higher during an oral glucose tolerance test (OGTT) indicates a higher risk for chronic kidney disease (CKD). This 1hPG cutoff helps identify individuals with increased CKD risk, even those with normal glucose tolerance.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic Syndrome

Background:

  • A 1-hour postload plasma glucose (1hPG) cutoff of 155 mg/dl identifies individuals at high risk for type 2 diabetes and vascular atherosclerosis.
  • The association between elevated 1hPG levels and chronic kidney disease (CKD) risk remains less understood.

Purpose of the Study:

  • To investigate if individuals with 1hPG ≥155 mg/dl are at increased risk for developing CKD.
  • To evaluate the utility of the 155 mg/dl 1hPG cutoff in identifying CKD risk.

Main Methods:

  • Analysis of atherosclerosis risk factors, oral glucose tolerance test (OGTT) results, and estimated glomerular filtration rate (eGFR) using the CKD Epidemiology Collaboration equation.
  • Study included 1075 white individuals without diabetes, assessing cardiometabolic profiles and CKD risk.

Main Results:

  • The 1-hour postload plasma glucose (1hPG) demonstrated the highest predictive value for identifying risk compared to other time points in the OGTT.
  • Individuals with 1hPG ≥155 mg/dl exhibited a poorer cardiometabolic risk profile and significantly lower eGFR.
  • Elevated 1hPG (≥155 mg/dl) was independently associated with an increased risk of CKD, even in individuals with normal glucose tolerance.

Conclusions:

  • A 1-hour postload plasma glucose cutoff of 155 mg/dl during OGTT is a valuable tool for identifying individuals at increased risk for CKD.
  • This finding suggests that 1hPG measurement can aid in early detection and management of CKD in at-risk populations.