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Related Experiment Videos

Vaginal infection and preterm labour.

H M McDonald1, J A O'Loughlin, P Jolley

  • 1Department of Microbiology, Queen Victoria Hospital, Adelaide Medical Centre for Women and Children.

British Journal of Obstetrics and Gynaecology
|May 1, 1991
PubMed
Summary

Specific vaginal microflora, including bacterial vaginosis and enteropharyngeal organisms, are significantly associated with preterm labor (PTL). These findings highlight potential microbial markers for predicting PTL onset in pregnant women.

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Area of Science:

  • Obstetrics and Gynecology
  • Microbiology
  • Reproductive Health

Background:

  • Preterm labor (PTL) remains a leading cause of neonatal morbidity and mortality.
  • The role of vaginal microflora in the onset of PTL is not fully understood.
  • Identifying microbial predictors of PTL is crucial for timely intervention.

Purpose of the Study:

  • To investigate the association between specific vaginal microflora and the onset of preterm labor (PTL).
  • To compare the vaginal microflora composition in women experiencing PTL versus those in labor at term.

Main Methods:

  • A prospective study involving microbiological assessment of vaginal flora in women during early labor.
  • Cultures for aerobic and anaerobic bacteria, yeasts, genital mycoplasmas, and Trichomonas vaginalis were performed.

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  • Multiple logistic regression analysis adjusted for obstetric and demographic variables.

    • Main Results:

    • Two distinct bacteriological groupings were significantly associated with PTL (less than 37 weeks gestation): bacterial vaginosis-associated organisms (Gardnerella vaginalis, Bacteroides spp.) and enteropharyngeal organisms (E. coli, Klebsiella spp., Haemophilus spp., S. aureus).
    • Prevalence of G. vaginalis and Bacteroides spp. was higher in PTL, particularly in women with PTL less than 34 weeks gestation.
    • Enteropharyngeal organisms were also more common in PTL, with increased isolation rates in women with PTL less than 34 weeks. Bacteroides spp., Klebsiella spp., and Haemophilus spp. were linked to preterm prelabour rupture of membranes (PPROM).

    Conclusions:

    • Two distinct bacteriological profiles are commonly identified in women experiencing PTL, especially before 34 weeks gestation.
    • These profiles include women with bacterial vaginosis and those with enteropharyngeal bacteria in the vagina.
    • The findings suggest that specific vaginal microbial compositions may serve as indicators for PTL risk.