A 10.0-mm posterior lamellar graft for bullous keratopathy in a buphthalmic eye

To report a case of Descemet stripping endothelial keratoplasty (DSEK) with a large posterior lamellar graft for the treatment of bullous keratopathy secondary to congenital glaucoma.

Bullous keratopathy secondary to unilateral congenital glaucoma with buphthalmos in a 36-year-old man was treated with DSEK. A Descemet endothelium lamella of 10-mm diameter was excised by descemetorhexis. A regular sclerocorneal donor button of 12-mm diameter was manually split using the Melles technique, and a 10-mm diameter donor graft was punched. The graft was implanted as a folded "Taco" into the anterior chamber using forceps and fixed to the host bed using an intracameral air bubble.

: Immediately after DSEK, the graft showed a small peripheral dehiscence of 1 × 3 mm, which resolved within 2 days. During 30 months of follow-up, the endothelial graft remained well centered, clear, and without any signs of graft rejection. Visual acuity improved from perception of hand movement before operation to 0.2 at 30 months after DSEK. Endothelial cell loss was 33% at 18 months, 44% at 24 months, and 47% at 30 months after operation. Maximum intraocular pressure was 15 mm Hg preoperatively and 16 mm Hg at the last follow-up.

DSEK using a corneal graft of 10.0-mm diameter obtained from a normal-sized donor button can be performed safely and effectively in cases of unilateral buphthalmos and secondary corneal decompensation, where a large recipient cornea requires an equivalently sized graft and transplantation of large amounts of donor endothelium.