Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High rate of biological loss in assisted reproduction: it is in the seed, not in the soil.

Reproductive biomedicine online·2010

Same author

High rate of biological loss in assisted reproduction: it is in the seed, not in the soil.

Reproductive biomedicine online·2007

Same author

The epilepsy, the protease inhibitor and the dodecamer: progressive myoclonus epilepsy, cystatin b and a 12-mer repeat expansion.

Cytogenetic and genome research·2003

Same author

Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein.

Genomics·2000

Same author

Refined genetic mapping of the autosomal recessive non-syndromic deafness locus DFNB8 on human chromosome 21q22.3.

Advances in oto-rhino-laryngology·2000

Same author

Altered spacing of promoter elements due to the dodecamer repeat expansion contributes to reduced expression of the cystatin B gene in EPM1.

Human molecular genetics·1999

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Preimplantation genetic diagnosis.

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. maria.lalioti@yale.edu

Minerva Ginecologica

|July 3, 2010

Summary

Preimplantation genetic diagnosis (PGD) screens embryos for genetic disorders and aneuploidy. Recent advances improve methodology, but ethical considerations for non-medical traits are emerging.

Area of Science:

Reproductive Medicine
Genetics
Embryology

Background:

Preimplantation genetic diagnosis (PGD) involves screening embryos for genetic conditions.
Key applications include diagnosing monogenic disorders and aneuploidy.

Purpose of the Study:

To review recent advancements in PGD methodologies.
To discuss the advantages, disadvantages, and challenges of these new techniques.
To explore ethical implications of expanding PGD for physical traits.

Main Methods:

Review of recent scientific literature on PGD techniques.
Analysis of PGD for monogenic disorders and aneuploidy screening (PGS).
Discussion of emerging technologies like complete genome screening.

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Related Experiment Videos

Last Updated: Jun 11, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Main Results:

PGD for monogenic disorders is highly successful but technically demanding.
Aneuploidy screening (PGS) is re-emerging with advanced complete genome screening.
Ethical debates surround PGD for non-medical physical traits.

Conclusions:

PGD methodologies continue to evolve, offering improved diagnostic capabilities.
The field faces technical challenges and ethical considerations.
Complete genome screening represents a significant advancement in aneuploidy detection.