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A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications

Baocun Zhu1, Xiaoling Zhang, Yamin Li

  • 1Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, PR China.

Chemical Communications (Cambridge, England)
|July 3, 2010
PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...