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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
TRAF-mediated regulation of immune and inflammatory responses
YaYa Wang1, Peng Zhang, YingFang Liu
1Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA.
Abstract:
The tumor necrosis factor (TNF) receptor-associated factor (TRAF) family consists of six mammalian members, and is shown to participate in signal transduction of a large number of receptor families including TNF receptor family (TNFR) and Toll-like receptors-interleukin-1 receptors (TLR-IL-1R) family. Upon receptor activation, TRAFs are directly or indirectly recruited to the intracellular domains of these receptors. They subsequently engage other signaling proteins to activate inhibitor of kappaB kinase (IKK) complex, TRAF family member-associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1) and inducible I kappaB kinase (IKK-i) (also known as IKKepsilon), ultimately leading to activation of transcription factors such as NF-kappaB and interferon-regulatory factor (IRF) to induce immune and inflammatory responses.
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