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Updated: Jun 11, 2026
07:10
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
Published on: April 21, 2019
Microarrayed allergen molecules for the diagnosis of allergic diseases
Adriano Mari1, Claudia Alessandri, Maria Livia Bernardi
1Center for Molecular Allergology, IDI-IRCCS, Via dei Monti di Creta 104, Rome, Italy. a.mari@panservice.it
Current Allergy and Asthma Reports
|July 3, 2010
Summary
Advances in biotechnology and microtechnology are revolutionizing allergy diagnostics. New methods for detecting specific immunoglobulin E (IgE) are improving the diagnosis of allergic diseases.
Area of Science:
- Immunology
- Biotechnology
- Medical Diagnostics
Background:
- IgE-mediated allergic diseases are globally prevalent, with diagnosis traditionally relying on skin tests and IgE testing.
- Significant progress in understanding allergen molecular structures over 30 years has enabled new diagnostic approaches.
Purpose of the Study:
- To review the evolution of allergy diagnostics.
- To highlight advancements in biotechnology for allergen availability and microtechnology for IgE detection.
Main Methods:
- Review of current diagnostic tools for specific IgE detection.
- Insight into biotechnological production of allergenic molecules (purified and recombinant).
- Discussion of microtechnology, specifically protein biochips, for IgE detection.
Main Results:
- Biotechnology has led to the availability of characterized allergenic molecules.
- Microtechnology, including protein biochips, is enabling routine IgE detection.
- Integration of these technologies with information technology offers new diagnostic concepts.
Conclusions:
- Modern biotechnology and microtechnology are transforming allergy diagnostics.
- The combination of molecular allergology, biochips, and IT is paving the way for innovative diagnostic strategies.
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