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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: Jun 11, 2026

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras
09:03

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras

Published on: December 22, 2010

Medaka fish stem cells and their applications.

MeiSheng Yi1, Ni Hong, ZhenDong Li

  • 1Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260, Singapore.

Science China. Life Sciences
|July 3, 2010
PubMed
Summary

Medaka fish are a favored vertebrate model for stem cell research, enabling breakthroughs in understanding pluripotency and cell fate. This research opens new avenues for regenerative medicine through stem cell-based therapies.

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Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras
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Microinjection of Medaka Embryos for use as a Model Genetic Organism
07:25

Microinjection of Medaka Embryos for use as a Model Genetic Organism

Published on: December 22, 2010

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Comparative Vertebrate Studies

Background:

  • Stem cells, found in embryos and adult tissues, are crucial for development and hold therapeutic potential.
  • Research on stem cell cultures has primarily focused on mouse and human models.
  • Medaka (Oryzias latipes) has emerged as a significant vertebrate model for stem cell research.

Purpose of the Study:

  • To review the advancements and significance of medaka as a model organism in stem cell research.
  • To highlight key breakthroughs in medaka stem cell biology.
  • To underscore the potential of medaka for developmental studies and regenerative medicine.

Main Methods:

  • Review of existing literature on medaka stem cell research.
  • Analysis of specific stem cell types derived from medaka, including embryonic stem (ES) cells and spermatogonia.
  • Examination of novel techniques such as haploid ES cell applications for cloning.

Main Results:

  • Medaka has yielded the first non-murine embryonic stem (ES) cells.
  • The first adult male stem cells (spermatogonia) capable of in vitro sperm production were derived from medaka.
  • Haploid ES cells in medaka have enabled semi-cloning, producing fertile offspring.

Conclusions:

  • Medaka represents a powerful and versatile vertebrate model for diverse stem cell research.
  • Breakthroughs in medaka stem cell biology offer significant insights into developmental processes.
  • The unique capabilities of medaka stem cells advance the field of regenerative medicine and reproductive technologies.