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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Plasticity00:58

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Jun 11, 2026

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats
08:59

Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats

Published on: June 22, 2015

Progress in neural plasticity.

XiaoHui Zhang1, Mu-Ming Poo2

  • 1Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. xhzhang@ion.ac.cn.

Science China. Life Sciences
|July 3, 2010
PubMed
Summary
This summary is machine-generated.

Neural circuits change based on use, impacting learning and memory. Recent Chinese research explores synaptic plasticity and beyond, revealing new insights into brain function.

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Last Updated: Jun 11, 2026

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Area of Science:

  • Neuroscience
  • Cellular and Molecular Biology

Background:

  • The nervous system exhibits use-dependent plasticity, where neural circuit structure and function are modified by neuronal activity.
  • Activity-dependent synaptic plasticity, particularly long-term potentiation (LTP), is crucial for cognitive functions like learning and memory.
  • This field has been a central focus in neuroscience since the discovery of LTP in 1973.

Purpose of the Study:

  • To highlight significant contributions by Chinese neuroscientists to the understanding of synaptic plasticity.
  • To review advancements in cellular and molecular mechanisms of plasticity.
  • To explore plasticity beyond synapses, including intrinsic neuronal excitability and neuron-glia signaling.

Main Methods:

  • Review of recent research findings from Chinese neuroscientists.
  • Analysis of studies on synaptic plasticity mechanisms.
  • Investigation into non-synaptic plasticity, including intrinsic neuronal properties and network activity.

Main Results:

  • Chinese researchers have made notable advancements in elucidating the cellular and molecular underpinnings of synaptic plasticity.
  • Significant findings include activity-dependent changes in intrinsic neuronal excitability.
  • Contributions extend to understanding dendritic integration, neuron-glia signaling, and neural network dynamics.

Conclusions:

  • Recent work by Chinese neuroscientists has significantly advanced the understanding of synaptic plasticity and its broader implications.
  • The research underscores the complexity of neural circuit adaptation.
  • These findings offer valuable insights into the neural basis of learning, memory, and other cognitive functions.