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Updated: Jun 11, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Apocrine hidradenocarcinoma of the scalp: a classification conundrum
Marc Cohen1, David S Cassarino, Hubert B Shih
1Division of Head and Neck Surgery, UCLA School of Medicine, 10838 Le Conte Ave, Rm 62-132 CHS, Los Angeles, CA 90095, USA. macohen@mednet.ucla.edu
Introduction:
The classification of malignant sweat gland lesions is complex. Traditionally, cutaneous sweat gland tumors have been classified by either eccrine or apocrine features.
Methods:
A case report of a 33-year-old Hispanic man with a left scalp mass diagnosed as a malignancy of adnexal origin preoperatively is discussed. After presentation at our multidisciplinary tumor board, excision with ipsilateral neck dissection was undertaken.
Results:
Final pathology revealed an apocrine hidradenocarcinoma. The classification and behavior of this entity are discussed in this report.
Conclusion:
Apocrine hidradenocarcinoma can be viewed as an aggressive malignant lesion of cutaneous sweat glands on a spectrum that involves both eccrine and apoeccrine lesions.
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