Related Experiment Video

Updated: Jun 11, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
12:03

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

Angiotensin II revisited: new roles in inflammation, immunology and aging

Ariela Benigni1, Paola Cassis, Giuseppe Remuzzi

  • 1Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

EMBO Molecular Medicine
|July 3, 2010
PubMed

Insights

The renin-angiotensin system (RAS) regulates blood pressure and has new roles in inflammation and fibrosis. Blocking Ang II signaling may offer therapeutic benefits for aging and inflammatory diseases.

Area of Science:

  • Physiology
  • Molecular Biology
  • Pathology

Background:

  • The renin-angiotensin system (RAS) is crucial for blood pressure regulation.
  • Recent studies reveal RAS involvement in inflammation and fibrosis.
  • Angiotensin II (Ang II) binding to AT(1) receptors generates free radicals, causing mitochondrial dysfunction and tissue damage.

Purpose of the Study:

  • To review the established and emerging roles of the renin-angiotensin system.
  • To explore the implications of Ang II signaling in inflammation, aging, and tissue injury.
  • To discuss the therapeutic potential of targeting Ang II signaling.

Main Methods:

  • Literature review of studies on the renin-angiotensin system.
  • Analysis of research on Ang II's role in inflammation, oxidative stress, and aging.
  • Synthesis of findings regarding therapeutic interventions.

Main Results:

  • RAS is implicated in inflammatory processes and fibrotic conditions.
  • Ang II signaling contributes to oxidative stress and mitochondrial dysfunction.
  • Blocking Ang II signaling demonstrates neuroprotective effects and promotes longevity in rodents.

Conclusions:

  • The renin-angiotensin system plays a significant role beyond cardiovascular regulation.
  • Targeting Ang II signaling presents a promising therapeutic strategy for inflammatory diseases and age-related tissue damage.
  • Further exploration of Ang II signaling in disease pathogenesis and aging is warranted.

More Related Videos

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls10:16

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

Published on: January 4, 2018

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Related Concept Videos

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...