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Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: Jun 11, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
07:35

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

[Non-allergic eosinophilic conjunctivitis].

Osmo Kari1, K Matti Saari, Tari Haahtela

  • 1HYKS:n iho- ja allergiasairaala, PL 160, 00029 HUS.

Duodecim; Laaketieteellinen Aikakauskirja
|July 6, 2010
PubMed
Summary

Non-allergic eosinophilic conjunctivitis (NAEC) is a common eye condition affecting middle-aged women, presenting allergy-like symptoms without an identifiable allergy. Treatment involves anti-inflammatory eye drops and long-term supportive therapies.

Area of Science:

  • Ophthalmology
  • Allergy and Immunology

Context:

  • Non-allergic eosinophilic conjunctivitis (NAEC) is a prevalent yet underrecognized ocular condition.
  • Often co-occurs with dry eye syndrome, predominantly affecting middle-aged to elderly women.
  • Presents with symptoms mimicking allergic conjunctivitis but lacks atopic allergy markers.

Purpose:

  • To describe the clinical characteristics and management of non-allergic eosinophilic conjunctivitis.
  • To differentiate NAEC from allergic conjunctivitis based on diagnostic criteria.
  • To outline current therapeutic strategies for NAEC.

Summary:

  • Initial treatment involves glucocorticoid antibiotic eye drops to reduce eosinophilic inflammation.
  • Long-term management typically includes mast cell stabilizers and lubricating eye drops.

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Conjunctival Commensal Isolation and Identification in Mice
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Conjunctival Commensal Isolation and Identification in Mice

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Last Updated: Jun 11, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
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A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

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In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
08:13

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

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Conjunctival Commensal Isolation and Identification in Mice
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Conjunctival Commensal Isolation and Identification in Mice

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  • Adjunctive therapies may involve short-term glucocorticoid courses or longer-term immunosuppressants.

    • Impact:

    • Improved understanding of NAEC can lead to more accurate diagnosis and targeted treatment.
    • Effective management can alleviate patient symptoms and improve quality of life.
    • Further research may elucidate underlying mechanisms and novel therapeutic targets for NAEC.