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Updated: Jun 11, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
Published on: May 31, 2018
Onionin A from Allium cepa inhibits macrophage activation
Mona El-Aasr1, Yukio Fujiwara, Motohiro Takeya
1Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.
Abstract:
Onionin A (1), a new, stable, sulfur-containing compound, was isolated from acetone extracts of bulbs of onion (Allium cepa), and its structure was characterized as 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophen-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis. This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages.
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