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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Genetic variants in MTNR1B affecting insulin secretion

Karsten Müssig1, Harald Staiger, Fausto Machicao

  • 1Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University, Member of the German Centre for Diabetes Research (DZD), 72076 Tübingen, Germany.

Annals of Medicine
|July 6, 2010
PubMed
Summary

The global rise in type 2 diabetes is linked to genetic factors and lifestyle. Melatonin system alterations, particularly involving melatonin receptors, may significantly increase diabetes risk by affecting pancreatic beta-cell function.

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