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Related Experiment Video

Updated: Jun 11, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Microcirculatory dysfunction in sepsis.

Vanina Kanoore Edul1, Gonzalo Ferrara, Arnaldo Dubin

  • 1Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.

Endocrine, Metabolic & Immune Disorders Drug Targets
|July 6, 2010
PubMed
Summary

Sublingual microcirculation alterations are common in sepsis and predict patient outcomes. These changes can be monitored at the bedside and may improve with treatment.

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Authors reply: "Different microcirculatory pattterns in patients with COVID-19 and non-COVID-19 ARDS: A multicenter cross-sectional study".

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Effects of fluids on sublingual microcirculation: a point of view review.

Annals of intensive care·2025

Area of Science:

  • Physiology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • The sublingual microcirculation plays a crucial role in sepsis pathophysiology.
  • Advancements in videomicroscopy enable bedside evaluation of microcirculation in critically ill patients.

Purpose of the Study:

  • To review the pathophysiology of microcirculation in health and disease.
  • To examine sublingual microcirculatory alterations in septic patients and their prognostic value.
  • To discuss the impact of therapeutic interventions on sublingual microvascular changes.

Main Methods:

  • Review of experimental and clinical studies on microcirculation.
  • Application of videomicroscopic techniques for bedside monitoring.
  • Analysis of sublingual microcirculation in septic patients.

Main Results:

  • Severe microcirculatory alterations are present in septic patients.
  • Sublingual microcirculatory changes have significant prognostic value.
  • Therapeutic interventions can modify sublingual microvascular alterations.

Conclusions:

  • Sublingual microcirculation is a key indicator in sepsis.
  • Bedside monitoring of sublingual microcirculation offers prognostic insights.
  • Targeting microcirculatory dysfunction is a potential therapeutic strategy in sepsis.

Related Experiment Videos

Last Updated: Jun 11, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024