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Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
07:02

Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice

Published on: August 24, 2011

Time course of plasma microparticle concentrations after acute spontaneous basal ganglia hemorrhage

X-Q Dong1, M Huang, Y-Y Hu

  • 1Department of Neurosurgery, The First Hangzhou Municipal People's Hospital, Nanjing Medical University, 261 Huansha Road, Hangzhou, China. ysbdxq@163.com

Acta Neurologica Scandinavica
|July 6, 2010
PubMed
Abstract

Insights

Plasma microparticle (MP) levels are elevated after intracerebral hemorrhage (ICH) and predict poor outcomes. Higher MP levels correlate with mortality risk and acute phase response markers.

Area of Science:

  • Neuroscience
  • Hematology
  • Biochemistry

Background:

  • Intracerebral hemorrhage (ICH) is a severe neurological condition with high mortality.
  • Plasma microparticles (MPs) are small vesicles released from cell membranes, implicated in various pathological processes.

Purpose of the Study:

  • To investigate plasma microparticle (MP) levels in patients following intracerebral hemorrhage (ICH).
  • To assess the association between MP levels, clinical outcomes, and acute phase response markers.
  • To determine if MP levels can predict mortality after ICH.

Main Methods:

  • Plasma samples were collected from 86 acute ICH patients and 30 healthy controls at multiple time points post-ICH.
  • Procoagulant potential of MPs was quantified using a prothrombinase assay.
  • Statistical analyses, including multivariate analysis and ROC curve analysis, were performed.

Main Results:

  • Patients with ICH exhibited significantly higher plasma MP levels compared to healthy controls throughout the 7-day observation period.
  • Plasma MP levels were strongly correlated with patient outcomes and biological markers of the acute phase response.
  • Baseline plasma MP levels were identified as a significant predictor of 1-week mortality (OR 1.930, P=0.004).
  • A cutoff MP level of 8.4 nmol/l phosphatidylserine equivalent predicted 1-week mortality with 90.6% sensitivity and 68.5% specificity (P<0.001).

Conclusions:

  • Elevated plasma microparticle levels are a common finding after intracerebral hemorrhage.
  • Increased MPs may contribute to secondary brain injury and are associated with poor clinical outcomes.
  • Plasma MP levels serve as a valuable prognostic biomarker for mortality risk in ICH patients.

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