Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of reduced Cu,Zn-superoxide dismutase with coronary microvascular dysfunction-An observational study of oxidative stress markers.

International journal of cardiology. Heart & vasculature·2026

Same author

Postural stability in patients with vestibular migraine and probable vestibular migraine in the absence of acute vestibular symptoms.

American journal of otolaryngology·2024

Same author

Cell Type-Specific Relationships Among Immune Cells in Human Aortic Dissection Tissue.

The Kurume medical journal·2024

Same author

Analysis of postural stability using foam posturography in patients with persistent postural-perceptual dizziness.

Journal of vestibular research : equilibrium & orientation·2023

Same author

Asymmetrically Functionalized Electron-Deficient π-Conjugated System for Printed Single-Crystalline Organic Electronics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023

Same author

Antibody Response to the BA.5 Bivalent Vaccine Shot: a Two-Year Follow-Up Study following Initial COVID-19 mRNA Vaccination.

Microbiology spectrum·2023

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Gender differences in hand grip power in the elderly.

Shinichi Demura¹, Hiroki Aoki, Hiroki Sugiura

¹Kanazawa University Graduate School of Natural Science and Technology, Kakuma, Kanazawa, Ishikawa 920-1192, Japan.

Archives of Gerontology and Geriatrics

|July 6, 2010

Summary

Elderly males exhibit greater hand grip power than females, primarily due to higher maximum voluntary contraction (MVC). Age-related declines in muscle contraction velocity may impact males more significantly.

More Related Videos

Measurement of Spatial Stability in Precision Grip

Measurement of Spatial Stability in Precision Grip

Published on: June 4, 2020

Evaluating the Function of the Foot Core System in the Elderly

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

Related Experiment Videos

Last Updated: Jun 11, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Measurement of Spatial Stability in Precision Grip

Measurement of Spatial Stability in Precision Grip

Published on: June 4, 2020

Evaluating the Function of the Foot Core System in the Elderly

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

Area of Science:

Gerontology
Human Physiology
Biomechanics

Background:

Hand grip power is a key indicator of overall strength and health in older adults.
Previous research suggests potential sex-based differences in muscle function among the elderly.

Purpose of the Study:

To investigate and quantify the differences in hand grip power between elderly males and females.
To explore the relationship between maximum voluntary contraction (MVC) and hand grip power in both sexes.

Main Methods:

15 elderly males and 15 elderly females participated.
Hand grip power was assessed using dominant hand measurements at 30%, 40%, and 50% of maximum voluntary contraction (MVC).
Peak velocity and time to reach peak velocity were recorded.

Main Results:

Elderly males demonstrated significantly higher MVC than elderly females.
Hand grip power was significantly greater in males across all tested loads.
No significant differences were observed in peak velocity or time to reach peak velocity between sexes.

Conclusions:

Elderly males possess superior hand grip power compared to elderly females.
The observed gender difference in hand grip power is largely attributable to differences in MVC.
Age-related decreases in muscle contraction velocity might be more pronounced in elderly males.