Related Experiment Video
Updated: Jun 11, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Minimized doses for linear accelerator radiosurgery of brainstem metastasis
Charles A Valery1, Christos Boskos, Gilbert Boisserie
1Department of Neurosurgery, Assistance Publique des Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Paris, France. charles.valery@psl.aphp.fr
Summary
Reduced dose radiosurgery for brainstem metastases offers effective local control and survival rates comparable to higher doses. This approach minimizes severe side effects in patients with brain metastases.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Brainstem metastases pose treatment challenges due to the organ's critical neurological function.
- Conventional treatment strategies carry risks for neurological damage.
Purpose of the Study:
- To evaluate the efficacy and safety of reduced-dose micromultileaf linear accelerator (LINAC)-radiosurgery for brainstem metastases.
- To compare outcomes with previously reported higher-dose treatments.
Main Methods:
- Retrospective study of 30 patients treated between 2005-2007.
- Micromultileaf collimator 6-MV LINAC delivered radiation.
- Mean follow-up of 311 days; median patient age 57 years.
Main Results:
- 100% local control at 3 and 6 months, 79% at 12 months.
- Median survival of 10 months; median neurological control of 5 months.
- No severe side effects (Grade III-IV RTOG) observed.
Conclusions:
- Lower radiation doses can achieve comparable local control and survival rates for brainstem metastases.
- Reduced-dose radiosurgery presents a safe and effective treatment option with minimal toxicity.
