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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
Published on: February 17, 2019
[Normal tissue tolerance to external beam radiation therapy: small bowel].
E Martin1, Y Pointreau, S Roche-Forestier
1Département de Radiothérapie, Centre Georges-Francois-Leclerc, 1 Rue du Professeur-Marion, 21079 Dijon cedex, France.
Summary
Radiation therapy for abdominal cancers can damage the small intestine, causing acute issues like diarrhea and late effects such as chronic diarrhea and malabsorption. Irradiated small bowel volume correlates with toxicity risk.
Area of Science:
- Gastroenterology
- Radiation Oncology
Background:
- The small intestine plays a crucial role in food transit and nutrient absorption.
- Its anatomical location exposes it to ionizing radiation during abdominal and pelvic radiotherapy for various cancers.
Purpose of the Study:
- To analyze the acute and late side effects of small bowel irradiation.
- To establish correlations between irradiated small bowel volume and toxicity.
- To evaluate the potential impact of modern radiotherapy techniques on small bowel toxicity.
Main Methods:
- Literature analysis of small bowel exposure to ionizing radiation during radiotherapy.
- Correlation assessment between irradiated small bowel volume and acute toxicity.
- Review of dose thresholds associated with small bowel toxicity.
Main Results:
- Acute radiation effects include diarrhea, abdominal pain, and bloating.
- Late effects encompass chronic diarrhea, malabsorption, obstruction, bleeding, and fistulas.
- A significant correlation exists between the irradiated small bowel volume and acute toxicity, irrespective of the dose.
Conclusions:
- Recommended volume thresholds for small bowel receiving 15 Gy (100-200 cm³), 30 Gy, and 50 Gy (35-300 cm³) should be considered to mitigate toxicity.
- Modern conformal radiotherapy techniques may reduce small bowel toxicity.
