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[Normal tissue tolerance to external beam radiation therapy: bone marrow].

F Drouet¹, J-L Lagrange

¹Service de Radiothérapie, Centre René-Gauducheau, Boulevard Jacques-Monod, 44805 Saint-Herblain cedex, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique

|July 6, 2010

Summary

Reducing radiation dose to active bone marrow (ABM) is crucial for preventing hematologic toxicities. Recent studies, including those using intensity-modulated radiation therapy (IMRT), confirm that minimizing ABM exposure improves patient outcomes.

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Published on: February 17, 2019

Area of Science:

Radiation Oncology
Hematology
Medical Physics

Context:

Bone marrow is a critical organ sensitive to radiation therapy.
Its complex structure and function influence radiation-induced injury.
Understanding bone marrow's response is key to managing radiotherapy side effects.

Purpose:

To explore the relationship between bone marrow irradiation and hematological tolerance.
To investigate the impact of radiation dose and volume on blood cell counts.
To evaluate the role of intensity-modulated radiation therapy (IMRT) in mitigating toxicity.

Summary:

Bone marrow is a major dose-limiting tissue in radiotherapy.
Variations in radiation fields and doses significantly impact hematopoietic bone marrow.
Reducing bone marrow exposure, particularly with IMRT, helps prevent hematological toxicities.

Impact:

Minimizing irradiated bone marrow volume is essential for patient tolerance.
This knowledge aids in forecasting and managing radiation-induced bone marrow injury.
Further research is needed to define optimal bone marrow volume contours for radiation planning.