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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
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Published on: September 13, 2018

Modularity in the Hippo signaling pathway.

Marius Sudol1, Kieran F Harvey

  • 1Weis Center for Research, Laboratory of Signal Transduction, Geisinger Clinic, Danville, PA 17822, USA. msudol1@geisinger.edu

Trends in Biochemical Sciences
|July 6, 2010
PubMed
Summary
This summary is machine-generated.

The Hippo pathway regulates organism size through complex signaling. Its modularity, particularly the widespread WW domain, aids molecular analysis and component prediction.

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Metazoans possess pathways to control organ and organism size.
  • The Salvador-Warts-Hippo (Hippo) pathway is a key regulator of this process.
  • Research on the Hippo pathway has expanded significantly, revealing a complex signaling network.

Purpose of the Study:

  • To explore the modularity within the complex Hippo signaling network.
  • To investigate the role of the WW module in Hippo pathway components.
  • To propose how WW domain prevalence can aid pathway analysis.

Main Methods:

  • Literature review and analysis of existing Hippo pathway research.
  • Examination of protein domain occurrences within the Hippo pathway.
  • Hypothesis generation based on observed modularity.

Main Results:

  • The Hippo pathway exhibits significant modularity.
  • The WW domain is unusually prevalent across core kinase, upstream regulatory, and downstream nuclear components.
  • This WW domain-mediated complex formation is a key feature of the pathway's organization.

Conclusions:

  • The modular nature of the Hippo pathway, especially WW domain-mediated interactions, simplifies its study.
  • The prevalence of WW domains suggests a powerful tool for predicting novel pathway components.
  • Understanding this modularity facilitates deeper molecular analysis of Hippo signaling.