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Pregnancy and progression of IgA nephropathy: results of an Italian multicenter study
Monica Limardo1, Enrico Imbasciati, Pietro Ravani
1Department of Nephrology, Dialysis and Transplantation, A. Manzoni Hospital, Lecco, Italy.
Background:
Whether pregnancy impacts on the long-term outcome of immunoglobulin A (IgA) nephropathy is unknown. This study aims to compare the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function who did and did not become pregnant.
Study Design:
Multicenter longitudinal cohort study.
Setting & Participants:
Women of childbearing age with biopsy-proven IgA nephropathy, serum creatinine level
Predictors:
Pregnancy, treated as a time-dependent variable; baseline proteinuria; hypertension; and kidney biopsy histologic characteristics.
Outcome & Measures:
Rate of change in estimated creatinine clearance, change in proteinuria, and new-onset hypertension.
Results:
245 patients were enrolled. Of these, 223 women (136 and 87 in the pregnancy and nonpregnancy groups, respectively) had serum creatinine levels
Limitations:
Unrecognized or unmeasured factors associated with the decision of becoming pregnant might have influenced results.
Conclusions:
Pregnancy does not seem to affect the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function.
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