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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: Jun 11, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Targeting breast cancer stem cells.

Sean P McDermott1, Max S Wicha

  • 1Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, 6303 Comprehensive Cancer Center, Ann Arbor, MI 48109, USA.

Molecular Oncology
|July 6, 2010
PubMed
Summary
This summary is machine-generated.

The cancer stem cell (CSC) hypothesis suggests tumors are driven by self-renewing CSCs. Targeting these crucial cancer stem cells is essential for achieving a cure, especially in breast cancer treatment.

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Last Updated: Jun 11, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
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Published on: October 2, 2020

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Therapeutics

Background:

  • The cancer stem cell (CSC) hypothesis proposes that tumors originate from and are sustained by a small population of self-renewing cancer stem cells.
  • These CSCs possess the ability to differentiate, forming the bulk of the tumor, and are implicated in tumor recurrence post-therapy.
  • Identifying the precise cell of origin for cancer remains a challenge, though tissue-resident stem or progenitor cells are considered likely candidates for transformation.

Purpose of the Study:

  • To review current approaches for targeting cancer stem cells (CSCs) in breast cancer.
  • To discuss the challenges and potential of developing CSC-specific therapeutics.
  • To explore strategies for identifying CSC vulnerabilities and therapeutic agents.

Main Methods:

  • Review of studies focusing on targeting known stem cell regulatory pathways.
  • Discussion of unbiased high-throughput screening methods (siRNA, small molecules) for identifying novel CSC targets.
  • Analysis of similarities between normal and malignant stem cells (surface proteins, pathways, quiescence, miRNA) to inform therapeutic development.

Main Results:

  • Similarities between normal and cancer stem cells present therapeutic challenges.
  • Targeting known stem cell pathways and identifying novel vulnerabilities are key strategies.
  • Unbiased screening offers potential for discovering new therapeutic targets and agents for breast CSCs.

Conclusions:

  • Effective targeting of cancer stem cells is critical for achieving durable remission and cures.
  • Both pathway-targeted and unbiased screening approaches hold promise for developing novel breast CSC therapies.
  • Further research into CSC biology and therapeutic strategies is essential for improving cancer treatment outcomes.