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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

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Related Experiment Video

Updated: Jun 11, 2026

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
06:32

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts

Published on: April 13, 2022

Feeding and bone.

Jennifer S Walsh1, Dennis B Henriksen

  • 1Centre for Biomedical Research, Northern General Hospital, Sheffield S5 7AU, UK. jennifer.walsh2@sth.nhs.uk

Archives of Biochemistry and Biophysics
|July 6, 2010
PubMed
Summary
This summary is machine-generated.

Feeding acutely decreases bone resorption, influenced by diurnal rhythms. Research into these bone turnover mediators may yield new osteoporosis therapies, including gut and pancreatic peptides.

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Related Experiment Videos

Last Updated: Jun 11, 2026

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
06:32

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts

Published on: April 13, 2022

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolism

Background:

  • Bone turnover exhibits diurnal variation, influenced by feeding and fasting cycles.
  • Feeding acutely reduces bone resorption, mediated by complex physiological systems.
  • Understanding these mediators is crucial for developing novel osteoporosis treatments.

Purpose of the Study:

  • To review the current understanding of mediators controlling bone turnover in response to feeding.
  • To discuss clinical trial results of therapeutic agents targeting bone density.
  • To explore the potential bone effects of diabetes medications.

Main Methods:

  • Literature review of studies on diurnal bone turnover.
  • Analysis of research on calcitropic hormones, cortisol, gut peptides, and pancreatic peptides.
  • Examination of clinical trial data for ghrelin, amylin, and GLP-2 analogues.

Main Results:

  • Feeding triggers a decrease in bone resorption via various intermediary systems.
  • Clinical trials of ghrelin, amylin, and GLP-2 analogues show potential for treating low bone density.
  • GLP-1 mimetics used for type 2 diabetes may also impact bone health.

Conclusions:

  • Diurnal bone turnover regulation involves multiple hormonal and peptide systems.
  • Therapeutic strategies targeting these mediators offer promise for osteoporosis management.
  • Further research into the bone effects of metabolic drugs is warranted.