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Calcium oscillations in endothelial cells.

R Jacob1

  • 1Division of Biomedical Sciences, King's College, London, UK.

Cell Calcium
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Endothelial cells exhibit calcium oscillations ([Ca2+]i) that vary in pattern and synchrony. These oscillations impact blood flow, permeability, and cellular desensitization, highlighting their functional significance.

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Area of Science:

  • Cell Biology
  • Physiology

Background:

  • Endothelial cells display agonist-induced oscillations in cytosolic free calcium ([Ca2+]i).
  • Oscillation patterns vary, including repetitive spikes and sinusoidal waves, depending on endothelial cell type.

Purpose of the Study:

  • To describe properties of endothelial [Ca2+]i oscillations.
  • To assess human umbilical vein endothelial cell oscillations against a calcium-induced calcium release model.
  • To discuss functional implications of oscillation synchrony.

Main Methods:

  • Observation of cytosolic free calcium ([Ca2+]i) oscillations in endothelial cells.
  • Experimental manipulation including removal of extracellular Ca2+ and changes in membrane potential.
  • Assessment of spatial heterogeneity and synchrony of oscillations.

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Main Results:

  • Endothelial cells exhibit diverse [Ca2+]i oscillation patterns.
  • Oscillations are influenced by extracellular calcium and membrane potential.
  • Spatial heterogeneity and cell-to-cell synchrony of oscillations were observed.

Conclusions:

  • Endothelial [Ca2+]i oscillations are a complex phenomenon with varied characteristics.
  • Oscillation synchrony may play a role in regulating blood flow and transmural permeability.
  • Potential effects on cellular desensitization warrant further investigation.