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Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms
Thomas Perrier1, Patrick Saulnier, Florian Fouchet
1Inserm U646, Ingénierie de la vectorisation particulaire, Université d'Angers, 49100 Angers, France. thomas.perrier2@hotmail.fr
International Journal of Pharmaceutics
|July 6, 2010
Summary
Lipid NanoCapsules (LNCs) drug delivery systems were modified using a post-insertion method. Changing the surfactant
Area of Science:
- Drug delivery systems
- Nanotechnology
- Materials Science
Background:
- Lipid NanoCapsules (LNCs) are widely used for drug delivery.
- LNCs are typically prepared via a phase-inversion method.
- Post-insertion of amphiphiles is a known technique, often used with liposomes.
Purpose of the Study:
- To investigate the interfacial modifications of LNCs after post-insertion of distearoylphosphatidylethanolamine-peg amphiphiles.
- To understand the impact of varying the length and nature of the hydrophilic portion of the surfactant on LNC properties.
- To elucidate the mechanisms underlying the post-insertion process in LNCs.
Main Methods:
- Preparation of Lipid NanoCapsules (LNCs) using the phase-inversion method.
- Post-insertion of distearoylphosphatidylethanolamine-peg amphiphiles into the LNC shell.
- Characterization of LNC interfacial modifications using size and electrokinetic measurements.
Main Results:
- Successful molecular insertion of amphiphiles into the LNC shell was achieved.
- Modifications to the length and hydrophilic nature of the surfactant influenced LNC interfacial properties.
- Size and electrokinetic measurements provided insights into the post-insertion mechanisms.
Conclusions:
- The post-insertion method is effective for modifying LNC interfacial properties.
- Understanding these modifications is crucial for optimizing LNC-based drug delivery systems.
- Further research into surfactant-LNC interactions can enhance drug delivery efficacy.
