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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Bri2-23 is a potential cerebrospinal fluid biomarker in multiple sclerosis
Violaine K Harris1, Andrew Diamanduros, Pamela Good
1Multiple Sclerosis Research Center of New York, New York, NY 10019, USA.
Neurobiology of Disease
|July 6, 2010
Summary
Researchers identified seven proteins in cerebrospinal fluid as potential multiple sclerosis (MS) biomarkers. Decreased levels of the peptide Bri2-23 correlate with cerebellar dysfunction and cognitive impairment in MS patients.
Area of Science:
- Neuroscience
- Biochemistry
- Proteomics
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Identifying specific biomarkers for MS is crucial for diagnosis and understanding disease mechanisms.
- Cerebrospinal fluid (CSF) is a valuable source for biomarker discovery.
Purpose of the Study:
- To identify novel MS-specific protein biomarkers in CSF.
- To investigate the association of identified biomarkers with clinical manifestations in MS patients.
Main Methods:
- Proteomic screening of CSF from 40 MS patients and 13 controls.
- Statistical analysis to identify proteins with significantly altered levels.
- Clinical subgroup analysis correlating protein levels with neurological functions.
Main Results:
- Seven proteins (Beta-2-microglobulin, Bri2-23, Fetuin-A, Kallikrein-6, Plasminogen, Ribonuclease-1, and Transferrin) showed significantly altered levels in MS patients.
- Decreased CSF levels of Bri2-23 were significantly associated with cerebellar dysfunction and cognitive impairment.
- Reduced Bri2 expression was observed specifically in the cerebellum of MS patients.
Conclusions:
- CSF levels of Bri2-23 may serve as a potential biomarker for cerebellar dysfunction and cognitive impairment in MS.
- Decreased cerebellar Bri2 expression might contribute to cerebellar dysfunction in MS.
- Further research is warranted to validate Bri2-23 as an MS biomarker.
Related Concept Videos
01:21Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
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