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Published on: March 28, 2017
Arthropod CYPomes illustrate the tempo and mode in P450 evolution
1UMR1301 INRA CNRS Universite de Nice Sophia Antipolis, 400 Route des Chappes, 06903 Sophia Antipolis, France. rfeyer@sophia.inra.fr
Biochimica Et Biophysica Acta
|July 6, 2010
Summary
The diversity of cytochrome P450 (CYP) genes in insects, known as CYPomes, is largely explained by gene duplications and lineage-specific expansions. These "blooms" contribute significantly to CYPome diversity across species.
Area of Science:
- Genomics
- Evolutionary Biology
- Biochemistry
Background:
- The extensive diversity of P450 genes across organisms is recognized but lacks a clear explanation.
- The number of CYP genes varies significantly between species, particularly within arthropods and insects.
Purpose of the Study:
- To investigate the evolutionary mechanisms driving the expansion and diversity of CYP genes in arthropod CYPomes.
- To understand the origins of species- or lineage-specific expansions observed in CYP gene families.
Main Methods:
- Comparative genomic analysis of CYPomes, focusing on arthropods and insects.
- Application of stochastic birth and death models to explain gene proliferation.
- Analysis of gene duplication events and their role in subfamily expansions.
Main Results:
- Orthologous CYP genes represent a small fraction of the total CYPome.
- Species- and lineage-specific expansions, termed "blooms," are prevalent in insect CYPomes.
- Gene duplication is the primary driver of these CYP gene blooms, with varying expansion rates across subfamilies.
Conclusions:
- Stochastic models adequately explain CYP gene proliferation and blooms.
- Speciation events are crucial factors influencing CYPome diversity between lineages.
- Mitochondrial clan P450s show repeated blooms in insects, unlike in vertebrates.
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