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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

Haiyan Ying1, Lifen Yang, Guilin Qiao

  • 1Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.

Journal of Immunology (Baltimore, Md. : 1950)
|July 6, 2010
PubMed
Summary

The interaction between CTLA-4 and B7 inhibits T helper 17 (Th17) cell differentiation and suppresses autoimmune diseases. Blocking this interaction enhances Th17 responses and increases disease severity.

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