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Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...

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Updated: Jun 11, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
03:40

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A toxic shot from the hip.

Judith W P M Oomen1, Bart W Smits, Dorine W Swinkels

  • 1Department of Orthopedic Surgery 357, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands.

Journal of Neurology, Neurosurgery, and Psychiatry
|July 6, 2010
PubMed
Summary

A man developed a movement disorder due to lead toxicity from bullet fragments in his hip. Surgical removal of fragments and chelation therapy resulted in significant improvement.

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Area of Science:

  • Neurology
  • Toxicology
  • Orthopedic Surgery

Background:

  • Lead poisoning can present with diverse neurological symptoms, often delayed.
  • Trauma sites can serve as reservoirs for toxic substances, leading to chronic exposure.

Observation:

  • A 26-year-old male presented with a movement disorder including bradyphrenia, bradykinesia, rigidity, tremor, and dystonia.
  • Investigations revealed anemia and porphyria, with a history of a gunshot wound to the hip.
  • Neurological symptoms manifested years after the initial injury, suggesting a delayed toxic effect.

Findings:

  • The patient's neurological condition was diagnosed as lead toxicity.
  • Slow absorption of lead from retained bullet fragments in the hip joint was identified as the cause.
  • Laboratory tests confirmed elevated lead levels contributing to the movement disorder.

Implications:

  • This case highlights the potential for retained metallic fragments to cause chronic lead poisoning.
  • Prompt surgical intervention and chelation therapy can effectively manage lead toxicity-induced movement disorders.
  • Highlights the importance of considering environmental and historical exposures in diagnosing complex neurological conditions.