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Related Experiment Video

Updated: Jun 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Prophylactic platelet transfusions.

Lise J Estcourt1, Simon J Stanworth, Michael F Murphy

  • 1Haematology/Transfusion Medicine, NHS Blood & Transplant and the NIHR Biomedical Research Centre, Oxford, UK.

Current Opinion in Hematology
|July 6, 2010
PubMed
Summary
This summary is machine-generated.

Low-dose prophylactic platelet transfusions are effective for preventing bleeding, similar to high-dose transfusions. Platelet mass is a safe alternative trigger for transfusions in neonates, reducing overall requirements.

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Last Updated: Jun 11, 2026

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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Area of Science:

  • Hematology
  • Transfusion Medicine
  • Clinical Research

Background:

  • Prophylactic platelet transfusions remain a controversial topic in hematology.
  • Recent studies have introduced new findings and strategies for platelet transfusion protocols.

Purpose of the Study:

  • To review recent research on prophylactic platelet transfusions.
  • To highlight new findings from the last 12 months regarding transfusion strategies.

Main Methods:

  • Comparison of different doses of prophylactic platelet transfusions in randomized controlled trials (RCTs) for hematological malignancies.
  • Evaluation of platelet mass as a transfusion trigger in neonates.
  • Analysis of interim results from a trial comparing therapeutic versus prophylactic strategies in acute myeloblastic leukemia.

Main Results:

  • Low-dose prophylactic platelet transfusions demonstrated equal efficacy in bleeding prevention compared to high-dose transfusions.
  • Fewer platelets were transfused with low-dose protocols, but transfusion frequency increased.
  • Platelet mass as a trigger reduced prophylactic platelet needs in thrombocytopenic neonates without increasing bleeding risk.
  • Interim results for acute myeloblastic leukemia strategies were inconclusive, requiring further data from ongoing trials.

Conclusions:

  • Low-dose prophylactic platelet transfusions are a viable alternative to high-dose transfusions.
  • Platelet mass offers a potentially more efficient transfusion trigger in neonatal care.
  • Further research is needed to definitively establish the optimal transfusion strategy for acute myeloblastic leukemia.