Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Yellow Fever

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mortality predictors in a cohort of patients with COVID-19 admitted to a large tertiary hospital in the city of São Paulo, Brazil: a retrospective study.

Sao Paulo medical journal = Revista paulista de medicina·2022

Same author

Potentially inappropriate medication use in hospitalized elderly patients.

Revista da Associacao Medica Brasileira (1992)·2022

Same author

The effects of temperature variation treatments on embryonic development: a mouse study.

Scientific reports·2022

Same author

Risk of venous thromboembolism in users of contraception and menopausal hormone therapy during the COVID-19 pandemic.

Revista da Associacao Medica Brasileira (1992)·2020

Same author

Beers AGS 2019 criteria in very old hospitalized patients.

Revista da Associacao Medica Brasileira (1992)·2020

Same author

Over-the-counter medications potentially inappropriate for the elderly.

Revista da Associacao Medica Brasileira (1992)·2018

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue in an elderly patient.

Milton Luiz Gorzoni¹, Irineu Francisco Delfino Silva Massaia, Sueli Luciano Pires

¹Dom Pedro II Geriatric and Convalescent Hospital, Gerontology Discipline in Internal Medicine, Department at Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, SP, Brazil. hdp.dirtec@santacasasp.org.br

Revista Do Instituto De Medicina Tropical De Sao Paulo

|July 6, 2010

Summary

Elderly individuals face higher dengue risks. Self-medication with salicylates in older adults with dengue can worsen outcomes due to factors like prior infections and chronic conditions.

More Related Videos

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum

Published on: April 10, 2018

Related Experiment Videos

Last Updated: Jun 11, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum

A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum

Published on: April 10, 2018

Area of Science:

* Arbovirology
* Geriatric Medicine
* Public Health

Background:

* Elderly populations exhibit increased susceptibility to severe dengue.
* Clinical presentations and complications of dengue in older adults remain under-investigated.
* Dengue virus (DENV) poses a significant global health threat, particularly to vulnerable age groups.

Observation:

* A case report of an 80-year-old woman experiencing dengue complications following self-medication with salicylate.
* The patient's condition was potentially exacerbated by salicylate use, a common over-the-counter medication.
* This case highlights the need for careful consideration of drug interactions and patient history in elderly dengue patients.

Findings:

* Dengue in the elderly is associated with more severe clinical courses, higher hospitalization rates, and increased mortality.
* Factors contributing to severity include prior DENV serotype infections, comorbidities, immunosenescence, and polypharmacy.
* Salicylate use, in particular, may increase the risk of bleeding complications in dengue patients.

Implications:

* Public health strategies are needed to address the unique challenges of dengue management in the elderly.
* Healthcare professionals require enhanced awareness and specific guidelines for treating dengue in older adults.
* Further research into age-specific dengue pathophysiology and treatment is crucial for improving patient outcomes.