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Peritumoral brain edema in intracranial meningiomas

Nelson de Azambuja Pereira-Filho1, Fabiano Pasqualotto Soares, Ivan de Mello Chemale

  • 1Serviço de Neurologia e Neurocirurgia Dr. Mario Ferreira Coutinho, Hospital Beneficência Portuguesa de Porto Alegre, Porto Alegre RS, Brazil.

Arquivos De Neuro-Psiquiatria
|July 6, 2010
PubMed

Insights

Peritumoral brain edema (PBE) is common in meningiomas. Larger tumors and specific locations like the olfactory groove, along with the transitional histological subtype, are associated with increased PBE.

Area of Science:

  • Neurosurgery
  • Neuroradiology
  • Oncology

Background:

  • Peritumoral brain edema (PBE) is frequently observed in patients with meningiomas.
  • The exact pathophysiological mechanisms underlying PBE in meningiomas remain incompletely understood.
  • Several factors have been anecdotally linked to PBE, necessitating systematic investigation.

Purpose of the Study:

  • To investigate the correlation between the presence and degree of peritumoral brain edema (PBE) and various patient and tumor characteristics.
  • To analyze the influence of gender, age, tumor size, and histological subtype on PBE in meningioma patients.

Main Methods:

  • Retrospective analysis of MRI scans from 74 surgically treated meningioma patients.
  • Quantitative assessment of the presence and degree of peritumoral brain edema.
  • Statistical correlation of PBE findings with patient demographics and tumor parameters.

Main Results:

  • Peritumoral brain edema (PBE) was detected in 70.1% of the studied meningioma cases.
  • A significant positive correlation was observed between higher tumor volume and increased PBE.
  • Olfactory groove meningiomas exhibited more PBE compared to sphenoid wing and parasagittal tumors.
  • The transitional histological subtype was associated with a greater degree of PBE than fibroblastic and meningothelial subtypes.

Conclusions:

  • Tumor volume, anatomical location (olfactory groove), and histological subtype (transitional) are significant factors associated with peritumoral brain edema in meningiomas.
  • These findings contribute to a better understanding of PBE pathophysiology and may aid in pre-operative risk assessment and surgical planning.

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