Related Experiment Video
Updated: Jun 11, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
[Collagen cross-linking with riboflavin and UVA light]
A Hoyer1, E Spörl, L E Pillunat
1Augenklinik, Elblandklinikum Radebeul. Anne.Hoyer@elblandkliniken.de
Klinische Monatsblatter Fur Augenheilkunde
|July 6, 2010
Summary
Collagen cross-linking is an effective treatment for progressive keratoconus, stabilizing or improving vision in most patients. This minimally-invasive procedure offers significant clinical, economic, and psychosocial benefits.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Biomaterials Science
Context:
- Progressive keratoconus is a degenerative corneal disease.
- Collagen cross-linking (CXL) has emerged as a standard therapy since 1998.
- Defining progression criteria is crucial for patient selection.
Purpose:
- To evaluate the efficacy and long-term outcomes of collagen cross-linking for progressive keratoconus.
- To assess changes in visual acuity and corneal topography after CXL.
- To identify potential benefits and side effects of the procedure.
Summary:
- The study analyzed 153 eyes of 111 patients with a minimum 12-month follow-up.
- Corneal ectasia decreased by 2.28 D in the first year post-CXL.
- Visual acuity improved or remained stable in 73% of patients within the first year, with sustained results over two years.
Impact:
- Collagen cross-linking demonstrates long-term stabilization and improvement in progressive keratoconus.
- The treatment offers significant clinical, economic, and psychosocial advantages.
- CXL is an outpatient, minimally-invasive, and cost-effective therapeutic option.
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