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Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Methods for Studying Drug Absorption: In vitro01:16

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In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
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Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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Synthetic studies inspired by vinigrol.

Alexander D Huters1, Neil K Garg

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 6, 2010
PubMed
Summary

This review highlights recent advances in the total synthesis of vinigrol, a complex diterpene natural product. Key strategies from Baran, Barriault, Njardarson, and Hanna provide access to the vinigrol scaffold, driving innovation in synthetic chemistry.

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Area of Science:

  • Organic Chemistry
  • Natural Product Synthesis

Background:

  • Vinigrol is a complex diterpene natural product that has been a challenging target for chemists for over 20 years.
  • The intricate structure of vinigrol makes its total synthesis a significant benchmark in organic chemistry.

Purpose of the Study:

  • To review and highlight recent synthetic strategies for accessing the vinigrol scaffold.
  • To showcase the role of natural product synthesis in advancing chemical methodologies.

Main Methods:

  • The review summarizes key total synthesis approaches reported in the literature.
  • Focus is placed on the methodologies developed by Baran, Barriault, Njardarson, and Hanna.

Main Results:

  • Recent synthetic studies have successfully provided access to the vinigrol core structure.
  • Multiple elegant and innovative strategies have been employed to achieve the total synthesis.

Conclusions:

  • The total synthesis of vinigrol has been achieved through various innovative approaches.
  • Natural products continue to inspire and drive progress in the field of synthetic organic chemistry.