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Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
Published on: May 31, 2024
Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: implications for
J Carson Smith1, Eric S Paulson, Dane B Cook
1University of Wisconsin-Milwaukee, Department of Human Movement Sciences, P.O. Box 413, Milwaukee, WI 53201, USA. jcarson@uwm.edu
Journal of Neuroscience Methods
|July 7, 2010
Summary
Acute exercise increases cerebral blood flow (CBF), detectable with pulsed arterial spin labeling (PASL) at a 1,575 ms inversion time. This method reveals exercise impacts on motor cortex activity during tasks.
Area of Science:
- Neuroscience
- Exercise Physiology
- Medical Imaging
Background:
- Cerebral blood flow (CBF) changes post-exercise are not well-documented using arterial spin labeling.
- Pulsed arterial spin labeling (PASL) is a non-invasive MRI technique for measuring CBF.
Purpose of the Study:
- Determine the optimal inversion time (TI) for detecting exercise-induced CBF changes.
- Investigate if acute exercise alters motor cortex CBF at rest and during finger-tapping.
Main Methods:
- Five subjects underwent 30 minutes of moderate-intensity exercise.
- Relative CBF was measured using multi-TI PASL before and after exercise.
- Data acquired at rest and during 4 Hz finger-tapping across four inversion times (675-1575 ms).
Main Results:
- Global CBF increased by ~20% post-exercise, significantly detected at TI=1,575 ms (p<0.05).
- Finger-tapping showed significantly increased motor cortex CBF after exercise at TI=1,575 ms (p<0.01).
Conclusions:
- PASL at 3T with TI=1,575 ms can detect exercise-induced CBF alterations.
- Pre-exercise effects on motor cortex activation during tasks warrant consideration of physiological changes.
