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Related Experiment Video

Updated: Jun 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Protontherapy: basis, indications and new technologies].

A Mazal¹, J-L Habrand, S Delacroix

¹Institut Curie, Paris, France. alejandro.mazal@curie.net

Bulletin Du Cancer

|July 7, 2010

Summary

Proton therapy, with over 70,000 patients treated, offers precise radiation delivery for rare cancers. Advancements in technology and broader clinical applications, including common cancers and pediatrics, are expanding its potential, though challenges remain.

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Area of Science:

Medical Physics
Radiation Oncology
Particle Therapy

Background:

Proton therapy has treated over 70,000 patients globally, demonstrating significant clinical applications and technological evolution.
Its Bragg peak offers superior dose conformation to target volumes, proving effective for rare cancers like uveal melanomas and skull base chordomas/chondrosarcomas.

Purpose of the Study:

To review the evolution of clinical indications for proton therapy.
To explore the potential of new technological concepts in ion production for advancing proton therapy.

Main Methods:

Review of clinical outcomes and technological developments in proton therapy.
Discussion of emerging technologies like dielectric walls and laser-plasma interactions for ion production.

Main Results:

Proton therapy is increasingly considered for common cancers (prostate, lung, liver, ENT, breast) and pediatric programs.
Limited access to facilities and slow technical progress (ion production, beam shaping, verification) have challenged wider implementation.
Dynamic intensity-modulated techniques are a current challenge for clinical facilities.

Conclusions:

New technologies in ion production may lead to compact, cost-effective hospital-based proton therapy facilities.
The clinical feasibility of these advanced technological concepts requires further proof.