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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 11, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Primary cardiac synovial sarcoma.

Muhammad Talukder¹, Lyle Joyce, Randolph Marks

¹Division of Cardiovascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. mqitalukder@gmail.com

Interactive Cardiovascular and Thoracic Surgery

|July 7, 2010

Summary

This summary is machine-generated.

Synovial sarcoma is a rare heart tumor. This case shows improved survival outcomes for primary cardiac synovial sarcoma, even with recurrence.

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

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Published on: July 28, 2020

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Last Updated: Jun 11, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Area of Science:

Cardiovascular Pathology
Oncology
Sarcoma Research

Background:

Primary cardiac tumors are rare, with synovial sarcoma accounting for less than 1% of these.
Synovial sarcoma in the heart is exceptionally rare and typically associated with a poor prognosis, often with survival less than nine months.

Observation:

A case of primary cardiac synovial sarcoma was reported at Mayo Clinic, Rochester, Minnesota.
The patient presented with this rare cardiac malignancy.

Findings:

The patient remains alive 22 months post-surgery, despite some tumor recurrence.
This outcome suggests a potentially better prognosis than historically reported for this aggressive tumor type.

Implications:

This case highlights the possibility of longer survival for primary cardiac synovial sarcoma.
Further research into treatment strategies for this rare tumor is warranted to improve patient outcomes.