Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetic Model Based on Stochastic Simulation and Estimation for Therapeutic Drug Monitoring of Teicoplanin in Korean Neutropenic Hematopoietic Stem Cell Transplant Recipients.

Drug design, development and therapy·2026
Same author

Plasma glial fibrillary acidic protein as a potential biomarker for differentiating amyloid-negative subjective cognitive decline and mild cognitive impairment.

Journal of Alzheimer's disease : JAD·2026
Same author

Early diagnostic utility of BNP and NT-proBNP for cardioembolic stroke: A head-to-head comparison in the hyperacute and early acute phase.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
Same author

Diagnostic Performance of Eight Blood-based Biomarkers in a Well-characterized Korean Cohort of Preclinical Alzheimer's Disease.

Annals of laboratory medicine·2025
Same author

Gaps and Similarities in Research Use LOINC Codes Utilized in Korean University Hospitals: Towards Semantic Interoperability for Patient Care.

Journal of Korean medical science·2025
Same author

Dysbiosis of the initial stool microbiota increases the risk of developing necrotizing enterocolitis or feeding intolerance in newborns.

Scientific reports·2024

Related Experiment Video

Updated: Jun 11, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

[Bone marrow cellularity measurement by myelocrit].

Jiyoung Chang1, Hunhee Park, Hyojin Chae

  • 1Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea.

The Korean Journal of Laboratory Medicine
|July 7, 2010
PubMed
Summary

Myelocrit cellularity offers a simple, reproducible, and objective method for assessing bone marrow cellularity. For accurate evaluation, use the buffy coat layer for AML D7 marrow and myelocrit cellularity for other bone marrow samples.

More Related Videos

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
06:33

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Related Experiment Videos

Last Updated: Jun 11, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
06:33

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Area of Science:

  • Hematology
  • Biomedical Engineering
  • Medical Diagnostics

Context:

  • Bone marrow cellularity is a critical indicator for hematologic diseases.
  • Traditional microscopic evaluation of bone marrow cellularity suffers from observer variability.
  • Objective assessment methods are needed for reliable bone marrow evaluation.

Purpose:

  • To evaluate myelocrit cellularity as an objective method for determining bone marrow cellularity.
  • To compare the correlation of myelocrit cellularity and buffy coat layer thickness with conventional bone marrow cellularity.
  • To determine the optimal method for assessing bone marrow cellularity in different clinical contexts, including acute myeloid leukemia (AML) D7 marrow.

Summary:

  • Myelocrit cellularity, defined as the ratio of the buffy coat (BC) layer to the combined BC and fat layers after centrifugation of bone marrow aspirates, was assessed.
  • Both BC layer thickness and myelocrit cellularity showed good correlation with conventional bone marrow cellularity.
  • While BC layer thickness correlated with AML D7 marrow cellularity, myelocrit cellularity showed a stronger correlation with non-AML D7 bone marrow cellularity.

Impact:

  • Myelocrit cellularity provides a simple, reproducible, and objective alternative to subjective microscopic assessments of bone marrow cellularity.
  • The study recommends using BC layer thickness for AML D7 marrow and myelocrit cellularity for other bone marrow samples for more accurate cellularity assessment.
  • This method can improve the consistency and reliability of bone marrow evaluation in clinical practice and research.